Lands’ links

Lands, W.E.M. (1958) Metabolism of glycerolipides: A comparison of lecithin and triglyceride synthesis. J Biol Chem. 231(2):883-8.

Waku K, Lands WE. (1968) Control of lecithin biosynthesis in erythrocyte membranes. J Lipid Res. 1968 Jan;9(1):12-8. PubMed PMID: 5637422.

Lands WEM, Samuelsson B. (1968) Phospholipid precursors of prostaglandins Biochim. Biophys. Acta, 164 (1968) 426~429.

Lands, W.E.M., Culp, B.R., Hirai, A. and Gorman, R. (1985)  Relationship of Thromboxane Generation to the Aggregation of Platelets from Humans:  Effects of Eicosapentaenoic Acid.  Prostaglandins30, 819-825.

Fish and Human Health

Kulmacz, R.J., Pendleton, R.B., Lands, W.E.M.  (1994)  Interaction between peroxidase and cyclooxygenase activities in prostaglandin-endoperoxide synthase.  J. Biol. Chem., 269(8):5527-5536.

  1. Lands, W.E.M.(2003)  Diets could prevent many diseases.  Lipids38(4): 317-321.
  2. Lands, W.E.M.(2003)  Primary prevention in cardiovascular disease: moving out of the shadows of the truth about death.  Nutrition, Metabolism and Cardiovascular Diseases 13: 154-164.
  3. Hibbeln JR, Nieminen LR, Lands WE. (2004)Increasing homicide rates and linoleic acid consumption among five Western countries, 1961-2000. Lipids. 2004 Dec;39(12):1207-1213.
  4. Lands, WEM (2005) Alcohol: The balancing act. In: Preventive Nutrition, Third Edition(A Bendichand RJ Deckelbaum, eds.)  Humana Press, Totowa, NJ pp. 807-831.
  5. Lands, WEM (2005) Essential fatty acid metabolism to self-healing agents.In: Healthful Lipids(CC Akoh & O-M Lai, eds.) AOCS Press, Champaign, IL; pp.
  6. Lands WEM (2005) Dietary Fat and Health: The Evidence and the Politics of Prevention; Careful use of dietary fats can improve life and prevent disease.Annals NY Acad Sci.1055: 179-192.

Fish, Omega-3 and Human Health, Second Edition 2005

Lands WEM (2006) Learning how membrane fatty acids affect cardiovascular integrity, J. Membrane Biology 206(2): 75-83.

  1. Hibbeln JR, Nieminen LR, Blasbalg TL, Riggs JA, Lands WE.(2006) Healthy intakes of n-3 and n-6 fatty acids: estimations considering worldwide diversity. Am J Clin Nutr.
  2. Okuyama H, Ichikawa Y, Sun Y, Hamazaki T, Lands WE.-The cholesterol hypothesis – its basis and its faults. World Rev Nutr Diet. 2007;96:1-17.
  3. Okuyama H, Ichikawa Y, Sun Y, Hamazaki T, Lands WE.-Association of High Total Cholesterol with Coronary Heart Disease Mortality Differs among Subject Populations – Familial Hypercholesterolemia as a Key Concept. World Rev Nutr Diet. 2007;96:19-36.
  4. Okuyama H, Ichikawa Y, Sun Y, Hamazaki T, Lands WE.-Cancer and All-Cause Mortalities Are Lower in the Higher Total Cholesterol Groups among General Populations. World Rev Nutr Diet. 2007;96:37-54.
  5. Okuyama H, Ichikawa Y, Sun Y, Hamazaki T, Lands WE.-Pleiotropic effects of statins in the prevention of coronary heart disease – potential side effects. World Rev Nutr Diet. 2007;96:55-66.
  6. Okuyama H, Ichikawa Y, Sun Y, Hamazaki T, Lands WE.-Objective measures of the pathology of coronary heart disease.  World Rev Nutr Diet. 2007;96:67-82.
  7. Okuyama H, Ichikawa Y, Sun Y, Hamazaki T, Lands WE.-Omega3 Fatty Acids Effectively Prevent Coronary Heart Disease and Other Late-Onset Diseases – The Excessive Linoleic Acid Syndrome.  World Rev Nutr Diet. 2007;96:83-103.
  8. Okuyama H, Ichikawa Y, Sun Y, Hamazaki T, Lands WE.- Why Isn’t the Causal Relationship between Linoleic Acid and Mortalities from Coronary Heart Disease and Stroke Revealed by Clinical Studies?  World Rev Nutr Diet. 2007;96:105-18.
  9. Okuyama H, Ichikawa Y, Sun Y, Hamazaki T, Lands WE. 8.-Mechanisms by which dietary fats affect coronary heart diesease mortality.World Rev Nutr Diet. 2007;96:119-41.
  10. Okuyama H, Ichikawa Y, Sun Y, Hamazaki T, Lands WE. 9.- Cancers Common in the USA Are Stimulated by omega 6 Fatty Acids and Large Amounts of Animal Fats, but Suppressed by omega 3 Fatty Acids and Cholesterol. World Rev Nutr Diet. 2007;96:143-9.
  11. Okuyama H, Ichikawa Y, Sun Y, Hamazaki T, Lands WE. 10.- New directions of lipid nutrition for the primary and secondary prevention of coronary heart disease and other late-onset diseases. World Rev Nutr Diet. 2007;96:151-158.
  12. Lands WEM, Chapter 5. Tissue Omega-6 and Omega-3 Fatty Acids in Health and Disease.  in Wild-Type Food in Health Promotion and Disease Prevention(eds. F. DeMeester and R.R. Watson) pp. 51-53, Humana Press, Totowa, NJ  2007
  13. (special report) Barry London, Christine Albert, Mark E. Anderson, Wayne R. Giles, David R. Van Wagoner, Ethan Balk, George E. Billman, Mei Chung, William Lands, Alexander Leaf, John McAnulty, Jeffrey R. Martens, Rebecca B. Costello, David A. Lathrop.Omega-3 Fatty Acids and Cardiac Arrhythmias: Prior Studies and Recommendations for Future Research A Report from the NHLBI and ODS Omega-3 Fatty Acids and their Role in Cardiac Arrhythmogenesis Workshop.  2007 Sep 4;116(10):e320-335.
  14. Lands B.A critique of paradoxes in current advice on dietary lipids. Prog Lipid Res. 2008 Mar;47(2):77-106.
  15. (abstract) David R Van Wagoner, Don Wallick, Rashmi Ram, Fadia Mayyas, Laurie Castel, Beth Bunnell, Seiichiro Sakurai, Eui Seock Hwang, Douglas M Bibus, William E Lands. Dietary Omega-3 Fatty Acids Protect the Heart From Post-operative Atrial Fibrillation. American Heart Association Scientific Sessions 2008, Dallas, TX
  16. (letter) Ramsden CE, Hibbeln JR, Lands WE. Letter to the Editor re: Linoleic acid and coronary heart disease. Prostaglandins Leukot. Essent. Fatty Acids (2008), by W.S. Harris. Prostaglandins Leukot Essent Fatty Acids. 2009 Jan; 80(1): 77; author reply 77-8. Epub 2009 Jan 14. PubMed PMID: 19147338.
  17. (abstract) Rashmi Ram, Seiichiro Sakurai, Don W. Wallick,Eui-Seock Hwang, Fadia Mayyas, Beth S. Bunnell, Laurie Castel, Julie H. Rennison,  Douglas Bibus,  William E.M. Lands,  Mina K. Chung, and David R. Van Wagoner. Anti-inflammatory effects of omega-3 fatty acids contribute to antiarrhythmic efficacy.  American Heart Association, Heart Rhythm 2009, Annual Scientific Sessions, Boston, MA
  18. Lands WEM, Chapter 14. Human Life: Caught in the Food Web.  In Lipids in Aquatic Ecosystems(eds. M.T. Arts et al), pp. 327-354, 2009,  Springer Science + Business Media, LLC
  19. Lands B, Planning primary prevention of coronary disease. Curr Atheroscler Rep. 2009 Jul;11(4):272-80.
  20. Lands B, Measuring blood fatty acids as a surrogate indicator for coronary heart disease risk in population studies. World Rev Nutr Diet. 2009;100:22-34.  PubMed PMID: 19696524.
  21. Lands B, False profits and silent partners in health care. Nutr Health. 2009; 20(2):79-89.
  22. Lands B, Dietary n-3 and n-6 fatty acids compete for accumulation in tissues as 20- and 22-carbon highly unsaturated fatty acids (HUFA), Inform 2010; 21(7) 426-427.
  23. Smith WL, Lands B.Omega-6 fatty acids. In: Coates PM, Betz JM, Blackman MR, et al., eds. Encyclopedia of Dietary Supplements. 2d ed. New York and London: Informa Healthcare, 2010; 587-597.
  24. Mayyas F, Sakurai S, Ram R, Rennison JH, Hwang ES, Castel L, Lovano B, Brennan ML, Bibus D, Lands B, Barnard J, Chung MK, Van Wagoner DR. Dietary ω3 fatty acids modulate the substrate for post-operative atrial fibrillation in a canine cardiac surgery model. Cardiovasc Res. 2011 Mar 1;89(4):852-61. Epub 2010 Nov 30. PubMedPMID: 21123218
  25. Gordon Bell J, Mackinlay EE, Dick JR, Younger I, Lands B, Gilhooly T. Using a fingertip whole blood sample for rapid fatty acid measurement: method validation and correlation with erythrocyte polar lipid compositions in UK subjects. Br J Nutr. 2011 Jun 1; 106:1408-1415.
  26. Lands B, Prevent the cause, not just the symptoms. Other Lipid Med. 2011; 96: 90-93.
  27. Lands B, Everything is connected to everything else.Biol.Chem. 2011 Dec.23; 286(51): 43589-43595.
  28. Lin YH, Salem N Jr, Wells EM, Zhou W, Loewke JD, Brown JA, Lands WE, Goldman LR, Hibbeln JR. Automated high-throughput fatty acid analysis of umbilical cord serum and application to an epidemiological study. Lipids. 2012 May; 47(5): 527-539.
  29. Lands B, Lamoreaux E, Describing essential fatty acid balance as 3 – 6 differences rather than 3/6 ratios. Nutrition & Metabolism 2012, 9: 46-54.
  30. Lands B,Consequences of Essential Fatty Acids.Nutrients 2012, 4: 1338-1357.
  31. Lands B, Attention to Prevention, in Omega-6/3 Fatty Acids: Functions, Sustainability Strategies and Perspectives(eds. Fabien DeMeester, Ronald Ross Watson, Sherma Zibadi) 13-26; 2013 Humana Press/Springer
  32. Lands B, Healthy Fats and Oils: Balancing Omega-3 and Omega-6 Acids in Tissues in Immunonutrition: Interactions of Diet, Genetics, and Inflammation  (eds. Bharat Aggarwal and David Heber) 2014 CRC Press
  33. Lands B, Historical perspectives on the impact of n-3 and n-6 nutrients on health. Progress in Lipid Research 2014, 55: 17–29.
  34. Lands B. Dietary omega-3 and omega-6 Fatty acids compete in producing tissue compositions and tissue responses. Mil Med. 2014 Nov; 179 (11 Suppl):76-81. PubMed PMID: 25373089.
  35. Lands B. Omega-3 PUFAs lower the propensity for arachidonic acid cascade over-reactions. BioMed Research International Biomed Res Int. 2015;2015:285135. doi: 10.1155/2015/285135. PubMed PMID: 26301244. 〈〉
  36. Bibus D, Lands B. Balancing proportions of competing omega-3 and omega-6 highly unsaturated fatty acids (HUFA) in tissue lipids. Prost. Leuko. Essent. Fatty Acids 99 (2015) 19–23.
  37. Lands B. Choosing foods to balance competing n-3 and n-6 HUFA and their actions. OCL, DOI: 10.1051/ocl/2015017.
  38. Clark C., Lands B. Creating benefits from omega-3 functional foods and nutraceuticals. Food Nutr Sci. 2015;6:1613–23.
  39. Lands B. 2016. Fatty Acids: Essential Fatty Acids. In: Caballero, B., Finglas, P., and Toldrá, F. (eds.) The Encyclopedia of Food and Health 2016 vol. 2, pp. 615-622. Oxford: Academic Press.
  40. Lands B. 2016. Cholesterol: The Most Misunderstood Marker.In Handbook of Cholesterol: Biology, function and role in health and diseases. (ed. Ronald Watson, PhD and Fabien De Meester PhD) Wageningen Academic Publishers.
  41. Lands B.Omega 3 Fatty Acids Counterbalance Actions of Omega-6 Fatty Acids. In Fish and Fish Oils in Health and Disease(editors: Susan Raatz, Doug Bibus)2016  Elsevier
  42. Lands B. Benefit–Risk Assessment of Fish Oil in Preventing Cardiovascular Disease. Drug Safety, 2016, 39(9), 787-799. doi 10.1007/s40264-016-0438-5
  43. Strandjord SE, Lands B, Hibbeln JR. Validation of an equation predicting highly unsaturated fatty acid compositions of human blood fractions from dietary intake.  Prostaglandins Leukot Essent Fatty Acids. 2017 Mar 8. pii: S0952-3278(16)30157-0. doi:10.1016/j.plefa.2017.03.005. PubMed PMID: 28390839. 
  44. Lands B, Bibus D, Stark KD. Dynamic interactions of n-3 and n-6 fatty acid nutrients. Prostaglandins Leukot Essent Fatty Acids. 2017 Jan 25. pii:S0952-3278(16)30152-1. doi: 10.1016/j.plefa.2017.01.012. PubMed PMID: 28189338.
  45. Lands B. Highly unsaturated fatty acids (HUFA) mediate and monitor food’s impact on health. Prostaglandins Other Lipid Mediat. 2017 May 20. pii: S1098-8823(17)30003-5. doi: 10.1016/j.prostaglandins.2017.05.002. [Epub ahead of print]. PubMed PMID: 28535956.

Ramsden CE, Faurot KR, Zamora D, Suchindran CM, Macintosh BA, Gaylord S, Ringel A, Hibbeln JR, Feldstein AE, Mori TA, Barden A, Lynch C, Coble R, Mas E, Palsson O, Barrow DA, Mann JD. Targeted alteration of dietary n-3 and n-6 fatty acids for the treatment of chronic headaches: a randomized trial. Pain. 2013 Nov;154(11):2441-51. doi: 10.1016/j.pain.2013.07.028. Epub 2013 Jul 22. PubMed PMID: 23886520; PubMed Central PMCID: PMC3850757.
Ramsden CE, Faurot KR, Zamora D, Palsson OS, MacIntosh BA, Gaylord S, Taha AY, Rapoport SI, Hibbeln JR, Davis JM, Mann JD. Targeted alterations in dietary n-3 and n-6 fatty acids improve life functioning and reduce psychological distress among patients with chronic headache: a secondary analysisof a randomized trial. Pain. 2015 Apr;156(4):587-96. doi: 10.1097/01.j.pain.0000460348.84965.47. PubMed PMID: 25790451; PubMed Central PMCID: PMC5020375.
Ramsden CE, Zamora D, Majchrzak-Hong S, Faurot KR, Broste SK, Frantz RP, Davis JM, Ringel A, Suchindran CM, Hibbeln JR. Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73). BMJ. 2016 Apr 12;353:i1246. doi: 10.1136/bmj.i1246. PubMed PMID: 27071971; PubMed Central PMCID: PMC4836695.

Updated Sept., 2019