Research Stories of Omega 3-6 Balance – How we got to “NIX6 and EAT3“.

The efaeducation website site began long ago as dialog among NIAAA/NIH research scientists in the Laboratory of Membrane Biochemistry and Biophysics. They wanted the public to have easy access to research stories about essential fatty acids (EFA). Over time, the data grew into a body of knowledge that extends beyond the early ideas.

No person can ever step into the same river twice – Heraclitus noted that people and their environment continually change. Continual interactions of genes with their environment create a life that “surfs” on incoming waves of energy, nutrients and knowledge, changing from day to day, and differing year to year.

The list below points to evidence that gave insight and understanding about how omega-3 and omega-6 nutrients affect health. Eating balanced omega-3 and omega-6 nutrients balances the n-3 and n-6 highly unsaturated fatty acids (HUFA) stored in our tissues. A simple measure of each food item’s likely impact on your HUFA balance is posted on-line to help you NIX6 and EAT3The stored HUFA are precursors of a diverse set of hormones that act on specific receptors that signal in cells throughout the body, linking n-3 and n-6 nutrients to healthy physiology and pathophysiology.research on Omega 3-6 Balance

EFA Nutrients: their Diet-Tissue Dynamics give HUFA balance

HUFA Balance & Prostaglandins in Inflammatory Conditions

HUFA Balance in Successful Preventive Nutrition

Building the Brain: Maternal and infant needs

Signaling with synaptamide and phosphatidyl serine

G-protein coupled receptors (GPCR) act in Membrane Bilayers

HUFA and Depression

HUFA balance in mood, behavior, appetite and pain 

Ideas about Cholesterol – Clarifying Evidence

EFA, Seafood, Selenium & Mercury – Clarifying Evidence


revised February, 2018